IFOBT TF Only IFOBT Only TF BOTH Either P Valuef Positive patientsa 139(8.0) 184(10.6) 67(3.9) 112(6.4) 72(4.1) 251(14.5) 0.000 Colonoscopy performedb 109(78.4) 143(77.7) 50(74.6) 84(75.0) 59(81.9) 193(76.9) 0.730 Detection ratec 　 　 　 　 　 　 　 All advanced adenomas and cancer 28(1.6) 31(1.8) 15(0.9) 18(1.0) 13(0.7) 46(2.6) 0.034 Cancer 2(0.1) 2(0.1) 1(0.1) 1(0.1) 1(0.1) 3(0.2) 0.654 Advanced adenoma ≥10 mm 24(1.4) 22(1.3) 13(0.7) 11(0.6) 11(0.6) 35(2.0) 0.149 Advanced adenoma <10 mmd 2(0.1) 7(0.4) 1(0.1) 6(0.3) 1(0.1) 8(0.5) 0.057 Positive predictive valuee 　 　 　 　 　 　 　 All advanced adenomas and cancer 28(25.7) 31(21.7) 15(30) 18(21.4) 13(22.0) 46(23.8) 0.719 Cancer 2(1.8) 2(1.4) 1(2.0) 1(1.2) 1(1.7) 3(1.6) 0.854 Advanced adenoma ≥10 mm 24(22.0) 22(15.4) 13(26.0) 11(13.1) 11(18.6) 35(18.1) 0.414 Advanced adenoma <10 mmd 2(1.8) 7(4.9) 1(2.0) 6(7.1) 1(1.7) 8(4.1) 0.281 aRates are the number of positive patients relative to the number of participants. bRates are the number of colonoscoped patients relative to the number of positive patients. cDetection rate per protocol is the percentage of persons with lesions relative to the number of participants. d≥1 villous adenoma or adenoma with high-grade dysplasia and no adenomas ≥10 mm ePPV is the number of true positives relative to the number of total positive patients. followed up with colonoscopy. fTF combined with IFOBT (Either/or) vs IFOBT alone.

Table 1: Results of IFOBT and TF, either alone or combination, and subsequent colonoscopic findings in asymptomatic population (1737 participants), n(%).