Figure 4: Confounder-adjusted Cox proportional hazard regression analysis of metastases free survival in all patients (n = 318, UICC stage I-III). The green line denominates the patients receiving simultaneously to the conventional chemo- and/or radiotherapy a supportive Isc-Qu care. The red line denominates patients being only treated by conventional chemo- and/or radiotherapy. The hazard ratio (95% confidence intervals) was: HR = 0.31 (0.13-0.71), p = 0.006. HR indicates the confounder-adjusted hazard ratio (i.e. the estimated adjusted relative hazard to develop a distant metastasis in course of the study in the Isc-Qu group compared with the control group).