Therapeutic approach Metabolic target Agent
Inhibition of glycolysis Hexokinase Hexokinase VDAC complex Lactate dehydrogenase Pyruvate dehydrogenase kinase (PDK) Phosphofructokinase Pyruvate kinase (PK) 2-Deoxyglycose, 3-bromopyruvate, lonidamine. Methyl jasmonate Oxamate α-cyano-4-hydroxy cinnamic acid Dichloroacetate (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one CAP-232/TLN-232
Glutamine metabolism

Glutamine (analogs) Glutamine

6-Diazo-5-oxo-L-norleucine, azaserine L-Asparginine, Phenylbutyrate
PI3K/AKT/mTOR PI3K mTOR AKT LY294002, Wortmannin, GDC-0941, PX-866, CAL-101, BEZ235 and XL765. Temsirolimus (CCI779) and Everolimus (RAD001) Perifosine, PIAs Triciribine (API-2)
Table 1: Therapeutic strategies to target metabolic enzymes and relevant agents.