| Enzyme |
Pathway controlled |
Gene involved |
Isoform expressed in tumor cells |
Isoform expressed in normal cells |
| Hexokinase |
Glycolysis |
Hexokinase (HK) |
Hexokinase II (HK II) |
Hexokinase I, III, IV (HK I, III and IV) |
| Phosphofructokinase-2 (PFK-2) |
Glycolysis |
6-phospho-2-kinase/fructose2, 6-biphosphatase (PFKFB1-4) |
6-phospho-2-kinase/fructose2, 6-biphosphatase (PFKFB3 and PFKFB4) |
6-phospho-2-kinase/fructose2, 6-biphosphatase (PFKFB1 and PFKFB2) |
| Pyruvate Kinase |
Glycolysis |
Pyruvate Kinase M1 and M2 (PKM1 and PKM2) |
Pyruvate Kinase M2 (PKM2) |
Pyruvate Kinase M1 (PKM1) |
| Pyruvate dehydrogenase kinase (PDK) |
Between Glycolysis and TCA Cycle |
Pyruvate dehydrogenase kinase (PDK 1-4) |
Pyruvate dehydrogenase kinase (PDK)1 |
Pyruvate dehydrogenase kinase (PDK2, PDK3 and PDK4) |
| Glutaminase |
Glutamine metabolism |
Glutaminase 1 and Glutaminase 2 |
Glutaminase 2 |
Glutaminase 1 |