Variables

TT Genotype n(%)

TG Genotype n(%)

GG Genotype n(%)

T allele frequency

G allele frequency

Chi-Square

df

P –value

Gender
Males

26(23.2)

65(58.0)

21(18.8)

0.52

0.48

5.3

2

0.06

Females

2(8.3)

13(54.2)

9(37.5)

0.35

0.65

Age at diagnosis (Years)
≤45

3(13.6)

15(68.2)

4(18.2)

0.48

0.52

0.56

>45

25(21.9)

63(55.3)

26(22.8)

0.5

0.5

Histological Type
SCC

19(24.1)

41(51.8)

19(24.1)

0.5

0.5

2.41

2

0.29

ADC

9(15.8)

37(64.9)

11(19.2)

0.48

0.52

TNM Stage
Early Stage (I&II)

10(19.6)

36(70.6)

5(9.8)

0.55

0.45

8.09

2

0.01

Advanced Stage (III& IV)

18(21.1)

42(49.5)

25(29.4)

0.46

0.54

Metastasis
Positive

10(29.4)

11(32.4)

13(38.2)

0.46

0.54

12.03

2

0.002

Negative

18(17.6)

67(65.7)

17(16.7)

0.5

0.5

Family History of any Cancer
Significant

9(50.0)

8(44.4)

1(5.6)

0.72

0.28

0.004

Non Significant

19(16.1)

70(59.3)

29(24.6)

0.46

0.54

Smoking Status

 

 

Non Smoker

4(11.4)

24(68.6)

7(20.0)

0.46

0.54

3.05

2

0.22

Smokers

24(23.7)

54(53.5)

23(22.8)

0.5

0.5

Smoking Level ( Pack Year)
Mild (≤10)

0(0)

9(90.0)

1(10.0)

045

0.55

10.3

4

0.036

Moderate (≤40)

10(22.2)

27(60.0)

8(17.8)

0.52

0.48

Heavy (>40)

14(30.4)

18( 39.0)

14(30.4)

0.5

0.5

Smoking Type
Cigarette

8(27.6)

16(55.2 )

5(17.2)

0.55

0.45

0.99

Huka

7(27.0)

14(53.8)

5(19.2)

0.54

0.46

Bidi

3(23.0)

8(61.6)

2(15.4)

0.54

0.46

Cigarette+Bidi

1(9.0)

4(36.4)

6(54.6)

0.27

0.73

0.08

Cigarette+Huka

9(40.9)

12(54.5)

5(22.7)

0.58

0.42

Cytological Type
Squamous Cell Carcinoma
Well Differentiated

11( 25.5)

22(51.2)

10(23.3)

0.51

0.49

0.56

Moderately Differentiated

7(31.8 )

10(45.5)

5(22.7)

0.55

0.45

Poorly Differentiated

1(7.1 )

9(64.3 )

4(28.6)

0.39

0.61

Adenocarcinoma
Well Differentiated

2(18.2)

9(81.8 )

0(0 )

0.59

0.41

0.07

Moderately Differentiated

0(0)

12(75.0)

4(25.0)

0.38

0.63

Poorly Differentiated

7(23.3)

16(53.3)

7(23.3)

0.5

0.5

Table 2B: Associations and stratification analysis of MDM2 309T/G polymorphism and NSCLC.