Genes

Tissue (%)

Blood (%)

P Value

BRCA1 mRNA Altered Expression Normal Expression

 

2(10%) 18(90%)

 

0(15%) 20(100%)

 

P=0.002

BRCA2 mRNA Altered Expression Normal Expression

 

5(25 %%) 15(75%)

 

0(0.0%) 20(100%)

 

P=0.001

ER mRNA Altered Expression Normal Expression

 

9(45%) 11(55%)

 

1(5%) 19(95%)

 

P=0.014

PR mRNA Altered Expression Normal Expression

 

9(45%) 11(55%)

 

3(15%) 17(85%)

 

P=0.046

HER-2 mRNA Altered Expression Normal Expression

 

15(75%) 5(25%)

 

9(45%) 11(55%)

 

P=0.057

EGFR mRNA Altered Expression Normal Expression

 

11(55%) 12(60%)

 

 8(40%) 9(45%)

 

P=0.961

MET mRNA Altered Expression Normal Expression

 

10(50%) 10(50%)

 

4(20%) 16(80%)

 

P=0.052

PI3KCA mRNA Altered Expression Normal Expression

 

9(45%) 11(55%)

 

6(30%) 14(70%)

 

P=0.329

B-RAF mRNA altered Expression Normal Expression

 

5(25%) 15(75%)

 

0(0%) 20(100%)

 

P=0.001

PTEN mRNA Altered Expression Normal Expression

 

6(30%) 14(70%)

 

15(75%) 5(25%)

 

P=0.006

K-RAS mRNA Altered Expression Normal Expression

 

0(0%) 20(100%)

 

15(75%) 5(25%)

 

P=0.001

Table 3: qRT-PCR analysis of BRCA1, BRCA2, HER-2, ER, PR, PI3KCA, EGFR, MET, K-RAS and BRAF mRNA expression.