Genes

Altered Expression Blood

Genes

Altered Expression Tissue

BRCA1(N=0/20) Grade-I Grade-II Grade-III

0(0%) 0(0%) 0(0%)

BRCA1(N=2/20) Grade-I Grade-II Grade-III

1(50%) 0(0%) 0(0%)

BRCA2(N=0/20) Grade-I Grade-II Grade-III

0(0%) 0(0%) 0(0%)

BRCA2(N=5/20) Grade-I Grade-II Grade-III

1(20%) 3(60%) 1(20%)

HER-2(N=9/20) Grade-I Grade-II Grade-III

0(0%) 4(50%) 4(50%)

HER-2(N=15/20) Grade-I Grade-II Grade-III

2(14.3%) 7(50%) 5(35.7%)

ER(N=1/20) Grade-I Grade-II Grade-III

0(0%) 0(0%) 1(100%)

ER(N=9/20) Grade-I Grade-II Grade-III

1(11.1%) 6(66.7%) 2(22.2%)

PR(N=3/20) Grade-I Grade-II Grade-III

0(0%) 2(66.7%) 1(33.3%)

PR(N=9/20) Grade-I Grade-II Grade-III

1(11.1%) 7(77.7%) 1(11.1%)

PI3KCA(N=6/20) Grade-I Grade-II Grade-III

1(16.6%) 3(50%) 2(33.4%)

PI3KCA(N=9/20) Grade-I Grade-II Grade-III

1(12.5%) 3(37.5%) 4(50.0%)

EGFR(N=8/20) Grade-I Grade-II Grade-III

1(12.5%) 4(50%) 3(37.5%)

EGFR(N=11) Grade-I Grade-II Grade-III

1(9.1%) 7(63.6%) 3(27.3%)

MET(N=4/20) Grade-I Grade-II Grade-III

0(0%) 2(50%) 2(50%)

MET(N=10/20) Grade-I Grade-II Grade-III

2(20%) 5(50%) 3(30%)

B-RAF (0/20) Grade-I Grade-II Grade-III

0(0%) 0(0%) 0(0%)

B-RAF(5/20) Grade-I Grade-II Grade-III

1(20%) 4(80%) 0(0%)

K-RAS(15/20) Grade-I Grade-II Grade-III

2(13.3%) 8(53.3%) 5(33.4%)

K-RAS(0/20) Grade-I Grade-II Grade-III

0(0%) 0(0%) 0(0%)

PTEN (15/20) Grade-I Grade-II Grade-III

1(7.1%) 8(57.2%) 5(35.7%)

PTEN(6/20) Grade-I Grade-II Grade-III

0(0%) 3(50%) 3(50%)

Table 5: Correlation between multi gene expressions with histological grades.