Figure 4: Schematic representations of weak intramolecular interactions between BRCA1 BRCT wt and reported pathogenic mutations (i) BRCA1 BRCT M1775 (ii) BRCA1 BRCT M1775R (iii) BRCA1 BRCT P1749 (iv) BRCA1 BRCT P1749R (v) BRCA1 BRCT H1686 (vi) BRCA1 BRCT H1686Q (vii) BRCA1 BRCT S1715 (viii) BRCA1 BRCT S1715R. for clarity in Ligplot, the mutants are shown as B chain in this figure only.