Figure 1: An illustration of treatment schedule and timing of tissue harvest is shown for tissue samples used in the construction of the TMA. Animals were inoculated with tumor cells 7 days prior to treatment initiation. Animals were dosed daily for 7 days at time 0, 24, 48, 72, 96, 120, and 144 hours (solid arrows). Tumor tissue was harvested (dashed arrows) at 2, 4, 6 and 24 hours after the first treatment, and 6 hours after treatment on day 3 and 5. The last tumor harvest was performed 24 hours following the final treatment (168h).