Genes

6hr

12hr

24hr

CDK4

0.62

-0.01416

-1.3

Bcl-2

-1.21018

-3.30757

-3.44386

Rb

0.23648

0.14952

-0.64276

mutant Tp53

0.68784

0.022082

-2.12756

CD44

-0.62

-1.86

-2.4

SVV

-0.42

-0.5

-1.6

Table 1: The microarray data of the 6-combination targeted genes, showing a significant down-regulation at mRNA levels of anti-apoptotic proteins Bcl-2 and SVV, cancer cells migratory proteins CD44 and mutant p53 and down regulation of cell cycle regulatory proteins CDK4 and Rb. (negative values refer to fold change of down-regulated genes, the positive values refer to the fold change of up-regulated genes after the 6-combination treatment).