Figure 1a: Domain structure of SETD4 and comparative modeling. Schematic representation of the gene and primary protein structures of SETD4. Black boxes in the genes and white boxes in the mRNAs denote exons. The numbers above each gene are exon numbers. The numbers within the exons indicate their sizes in nucleotides. Thin lines in the genes indicate the introns and untranslated regions of the first and the last exons (mRNA, gray boxes). Gray and black boxes indicate SET and Rubis-subs-bind domains, respectively.