| AUTHOR/ YEAR |
MTX DOSE |
MTX INFUSION DURATION |
LEUCOVORIN RESCUE DOSE |
START OF LEUCOVORINa |
| ALL |
| Takeuchi 2002 [6] |
100 mg/m2bolus, then 500 mg/m2as a 4-hour infusion |
4 hours |
15 mg every 6 hours for 8 doses |
28 hours |
| Linker 2002 [7] |
220 mg/m2bolus, then 60 mg/m2per hr x 36 hours |
36 hours |
50 mg/m2IV every 6 hours for 3 doses, then orally until serum MTX < 0.05 μM |
36 hours |
| Han 2001 [8] Hill 2004 [9] |
8 g/m2(age ≤ 4)
6 g/m2(age > 4) |
10% bolus, remainder over 23 hours |
15 mg/m2every 3 hours, then every 6 hours when serum MTX
< 2 x 106μM |
36 hours |
| Pui 2004 [10] |
2 g/m2 |
2 hours |
10 mg/m2every 6 hours |
44 hours |
| Asselin 2011 [3] |
5 g/m2(0.5 g/m2bolus over 30 minutes, then 4.5 g/m2over 23.5 hours) |
24 hours |
75 mg/m2then 15 mg/m2every 6 hours until serum MTX ≤ 0.1 μM |
36 hours |
| CNS Lymphoma |
| Ferreri 2009 [4] Joerger 2010 [11] |
3.5 g/m2(0.5 g/m2in 15 minutes, then 3 g/m2as a 3- hour infusion) |
3 hours, 15 minutes |
15 mg/m2every 6 hours for 12 cycles or until serum MTX levels are undetectable |
24 hours |
| Osteosarcoma |
| Souhami 1997 [12] |
8 g/m2(≥ 12 years old)
12 g/m2(< 12 years old) |
Not specified |
12 mg/m2IV or 15 mg/m2orally every 6 hours for 10 doses |
24 hours |
| Fuchs 1998 [13] |
12 g/m2(maximum 20 g) |
Not specified |
15 mg/m2every 6 hours for 12 doses |
Not specified |
| Bacci 2001 [14] |
12 g/m2(escalate to 14 g/m2 if 6-hr serum MTX < 1 μM) |
6 hours |
15 mg every 6 hours for 11 doses |
24 hours |
| Goorin 2003 [15] |
12 g/m2 |
4 hours |
15 mg every 6 hours for 10 doses |
24 hours |
| Ferrari 2005 [16] |
12 g/m2 |
4 hours |
8 mg/m2every 6 hours for 11 doses |
24 hours |
| Holmboe 2012 [17] |
Mean dose, 12 g/m2
(range, 8-16 g/m2) |
4 hours |
Standard dosing until serum MTX ≤ 0.2 μM |
24 hours |