Figure 6: Representation of Fas-mediated apoptosis signalling [15]. Activation of caspase 8 through binding of Fas L to Fas receptor directly activates downstream caspases including caspases 3, 6, and 7. The mitochondrial amplification loop has been demonstrated to involve the caspase 8-mediated cleavage of Bid to tBid which results in the release of Smac/DIABLO from mitochondria.