Figure 7: Representation of TNF-R1-mediated apoptosis signalling [15]. The interaction of TNF with TNF receptor promotes the recruitment of TRADD. TRADD can interact with FADD and activate caspases 8/10. TRADD can also activate NF-kB which is anti-apoptotic. Release of Smac/DIABLO through tBid activation by caspase 8 inhibits XIAP and activates caspase 3.