TREATMENT PC3 LNCAP MCF7 Control 4.5 4 1.5 Nutlin 37 44.5 47.5 LM 0.5 nM 12 15.5 10.92 LM 1 nM 22 23 25.27 DR5 25 ng/ml 33.5 37.5 34 LM 0.5 nM + DR5 25 ng/ml 45.5 44.5 41.13 LM 1 nM + DR5 25 ng/ml 51 51 46.285 LM 0.5 nM + DR5 25 ng/ml + Nutlin 52.5 72.9 75.77 LM 1 nM + DR5 25 ng/ml + Nutlin 57 77.25 78.63

Table 8: Table comparing the effects of varying concentrations of leptomycin, DR5 and their combination with nutlin on PC3, LNCAP and MCF7 cells by using % apoptosis values.