Figure 7: Tumor volumes following implantation of MCF7 cells transfected with A) mock or B) Sirt7 RNAi in female NCr nude mice with and without doxorubicin (0.6 mg/kg) administered I.P. daily for 8 days. Transfection of MCF7 with Sirt7 RNAi resulted in slower growth rate when compared to mock transfected cells. Doxorubicin treatment inhibited tumor growth in mock transfected cells and had no significant effect on MCF7 cells transfected with Sirt7 RNAi. C) Tumor weight results were comparable to tumor volume results. Results are presented as mean ± SE; n=4; *: P<0.01.