Figure 1: A, Domain structures of PSF. The PSF protein (707 amino acids) contains two predicted RNA binding domains (RRM1 and RRM2), a proline-rich and glutamine-rich amino terminal domain, and two carboxy terminal nuclear localization signals. The first central region of the nucleotide-binding domain (NRM1) is required for the interaction with PPARγ. B, Structure of PPARγ1 and PPAR γ2. Human PPARγ1 and PPAR γ2 proteins are 53 and 57 kDa, respectively, based on the deduced amino acid sequences. The two PPARγ isoforms differ only 30 amino acids at the N-terminal end. These added amino acids on PPARγ2 result in increased adipose-selectivity.