Figure 7: Augmentation of uPA activity through uPA injection antagonized Serp-1 inhibition of pancreatic cancer growth. Hs766t cells suspended in uPA were injected subcutaneously into NOD/SCID mice, which then received Serp-1 or saline treatment with the same dosage and duration as described for prior studies. Serp-1 treatment no longer significantly inhibited macrophage infiltration in tumors (A, P=0.24, n=20 HPFs per group) or decreased MDSCs in the spleens (B, P=0.20, n=4 per group). (C)Tumor growth in these mice was not suppressed by Serp-1 treatment (P=0.26, n=4 per group).