Adverse Effect Symptoms Frequency (n=71) Relative frequency (%)
Gastrointestinal Diarrhea, nausea, vomiting, loss of appetite 56 79
Dermatologic Rash, redness, itching, peeling skin, hand-foot skin reaction (redness, pain, swelling or blisters on the palms of the hands or soles of the feet), wound healing problems 54 76
Metabolic Weight gain or weight loss, edema 43 61
Pain Skin pain, Pain in the stomach 32 45
Cardiovascular High blood pressure, failure of cardiac output, QT prolongation 24 34
Anemia   22 31
Neuropathy Pathologic skin sensations (tingling, burning, numbness) 18 25
Thrombocytopenia   15 21
Leukopenia   13 18
Neutropenia   10 14
Table 2: Common adverse effects of sorafenib, observed in a trial by Matei et al. [71] evaluated patients.