Angioinhibitor |
Parent molecule |
Targets |
Receptors |
Models of evaluation |
Collagenous derivatives |
Arresten |
collagen IV, α1 |
α1β1 integrin, HSPG |
Raf/MEK/ERK1/2/p38 MAPK HIF-1α |
In-vitro, Tumors studies |
Canstatin |
collagen IV, α2 |
αVβ3, αVβ5 integrins Fas |
procaspse-8 and -9
Akt/FAK/mToR/eIF-4EBP-1
Ribosomal S6-kinase |
In-vitro, Tumors, alkali burn CNV studies |
Tumstatin |
collagen IV, α3 |
CD47/IP,αVβ3, α6β1 integrins |
FAK/Akt/PI3K/mT R/eIF-
4E/4EBP1/NFκB/C X-2 |
In-vitro, Tumors studies |
Hexastatin |
collagen IV, α6 |
Not known |
Not known |
In-vitro, Tumors studies |
Endostatin |
collagen XVIII |
αVβ1/α5β1 integrins HSP, Glypican caveolin-1 |
Ras/Raf/KDR/Flk-1/ERK/
p38-MAPK\/p125FAK/HIF1
/Ephrin/TNF α/ NFκB /Wnt |
In-vitro, Tumors, CNV studies |
Pentastatins and Tetrastatins |
Collagen αV & αIV |
β1 and β3 integrins |
Not known |
In-vitro studies not known |
|