Angioinhibitor Parent molecule Targets Receptors Models of evaluation
Collagenous derivatives
Arresten collagen IV, α1 α1β1 integrin, HSPG Raf/MEK/ERK1/2/p38 MAPK HIF-1α In-vitro, Tumors studies
Canstatin collagen IV, α2 αVβ3, αVβ5 integrins Fas procaspse-8 and -9 Akt/FAK/mToR/eIF-4EBP-1 Ribosomal S6-kinase In-vitro, Tumors, alkali burn CNV studies
Tumstatin collagen IV, α3 CD47/IP,αVβ3, α6β1 integrins FAK/Akt/PI3K/mT R/eIF- 4E/4EBP1/NFκB/C X-2 In-vitro, Tumors studies
Hexastatin collagen IV, α6 Not known Not known In-vitro, Tumors studies
Endostatin collagen XVIII αVβ1/α5β1 integrins HSP, Glypican caveolin-1 Ras/Raf/KDR/Flk-1/ERK/ p38-MAPK\/p125FAK/HIF1 /Ephrin/TNF α/ NFκB /Wnt In-vitro, Tumors, CNV studies
Pentastatins and Tetrastatins Collagen αV & αIV β1 and β3 integrins Not known In-vitro studies not known
Table 1: Collage Derived Angioinhibitors.