| Angioinhibitor |
Parent molecule |
Receptors |
Targets |
Models of evaluation |
| Non-Collagenous derivatives |
| Angiostatin |
Plasminogen |
ATP synthases, αVβ3
integrin, angiomotin |
Apoptotic pathway |
In-vitro Tumor and CNV studies |
| Thrombospondins |
TSP |
CD36, IAP, CD47,
HSPG, α3β1, other
integrins |
Src-family kinases/Caspase-3/p38
MAPK, TGF-β |
In-vitro Tumor and CNV studies |
| Endorepellin |
Perlecan |
α2β1 integrins |
cAMP-PKA/FAK/p38-MAPK/Hsp27
SHP-1, Ca2+ |
In-vitro, Tumor studies |
| Vasoinhibins |
Prolactin, growth hormone, placental lactogen |
Not known |
Sos/Ras/MAPK, eNOs/Raf/MAPK,
Ca2+/eNOs/protein phosphatase
2, Ras/Tiam-1/Rac-1/Pak1, Bcl-
XL, NF-kβ |
In-vitro CNV studies |
| PEDF |
PEDF |
Not known |
Apoptosis |
In-vivo CNV studies |
|
