| Genotype |
Allele |
Country |
Type and size of the study |
Association |
OR / RR |
References |
| ERα- 397 T/C Pvull |
TT |
USA pre-andpostmenopausal |
Only Cases / Case Control 257/140 |
Diagnosis in youngerwomen |
|
Yaich et al. [9] |
| |
TT |
Shanghai, China |
Case / control 1069/1166 |
↑ risk for breastcancer |
OR: 1.4
IC 95%: 1.1-1.8
p= 0.042 |
Cai et al. [10] |
| |
TT |
Netherlands |
Case / control
380/422 |
↑ risk for breastcancer |
RR: 1.5
IC 95%: 0.94-2.42 |
Onland-Moret et al. [11] |
| |
TT |
China
25 a 55 years-old |
Case / control
259/278 |
↑ risk of breast cancer in women with a positive family history |
OR: 3.04
IC 95%: 0.73-12.67 |
Shen et al. [12] |
| |
TT |
Spain
26 to 86 years-old |
Case / control
444/704 |
↑ risk of breast cancer in women with a positive family history |
OR: 3.81
IC 95%: 1.25- 11.6 |
Gonzalez-Mancha et al. [13] |
| |
TT |
Netherlands
55 yearsor more |
Case / control
190/3513 |
↑ risk of breast cancer in women after menopause |
OR: 1.4
IC 95%: 0.8-2.2 |
Ladd et al.2007 [14] |
| |
TT |
USA peri-menopause 42 to 52 years-old |
longitudinal cohort
451 |
↑ Increased mammographic density in white women |
7,0%;
p=0,01 |
Crandall et AL
[15] |
| |
TT |
Brazil After-menopause |
Only cases 308women |
Mammographicdensity> 50% |
TT=32,14% greaterthan CC=20,13% |
Souza et al. [16] |
| |
TT/ TC |
Netherlandsand England After -menopause |
Population Cohort prospective case / control (795 withHT/781 with no HT) |
↑ Increased mammographic density only in HT users |
2.24%
p<0.01 |
van Duijnhoven et al.[17] |
| |
TC |
Netherlands |
Caso/controle380/422 |
↑ risk for BC |
OR: 1.14
IC 95%: 1.00-1.32 |
Onland-Moret et al. [11] |
| |
TC |
China
25 - 55 anos |
Case / control
259/278 |
↑ risk for BC(with family history) |
OR: 2.46
IC 95%: 0.61-9.88 |
Shen et al. [12] |
| |
CC |
Shanghai, China
22-64 years-old |
ProspectivePopulationCohort
1459 cases |
RE negative expression; worse prognosis for breast cancer |
OR: 3.30
IC 95%: 1.42-7.69 |
Boyapatti et al. [5] |
| |
CC |
Netherlands and England After- menopause |
Population Cohort prospective case / control [795/781] |
Mammographic density without changes in user HT |
0.90%
p= 0.47 |
van Duijnhoven et al.[17] |