Figure 2: Cluster analysis. (A) Hierarchical clustering of DNA methylation profiles using PHYLogeny Inference Package ( (B) Cluster overlay diagram. Left panel clinicopathologycal characteristics: Sample, Age, Sex, Clinical Stage pTNM, Localization, Size and Survival. Rigth panel, epigenetic profiles of RARĪ²2, RASSF1A, GSTP1, p16, Cyclin D2 and HIN-1 genes. Left numbers are PDA anonimized samples, and black blocks correspond to shared characteristics. Figure shows two matched groups (ie, upper lines tumors with the same pTNM and Localization are defined by just, and only, methylation in RASSF1A).