Immunoglobulin chain   Region   Number of Similarities   Percent Similarities  
    FR1   24/30   80%  
FR2 12/14 86%
FR3 27/37 73%
FR4   11/11 100%
Heavy Chain   Subtotal   74/82   80%
  CDR1   5/5   100%  
CDR2   11/11   100%  
CDR3   10/10   100%  
      Subtotal   26/26   100%
Total     100/108   93%  
  FR1 16/23 70%
FR2 14/15 93%
FR3 31/34 92%
FR4 9/10 90%
Light Chain   Subtotal   70/82   85%
  CDR1   17/17   100%  
CDR2 5/5 100%
CDR3 8/8 100%
  Subtotal   30/30   100%
Total     100/112   89%  
Heavy and Light Chain   Total 200/220 91%
Table 3: Comparisons of amino acid sequences homology in the FR and CDR domains in the Fab region of hGHR106and mGHR106.