c-Cbl expression APE1 expression Tissue NT T NT T Prostate w h w h Breast h h h h Ovary w h w h Uterus w h w h Brain w h w h Muscles w h w h Lung w h w h Liver h h w h Kidney h h h w Bladder h h w h Pancreas h h w h Lymph nodes w h nd nd Colon w h nd nd Rectum w h nd nd Skin h h nd nd Oesophagus h h nd nd Stomach h h nd nd

Table 1: Summary of c-Cbl expression and corresponding APE1 expression in non-tumoral and tumoral human tissues. APE1 reflects the oxidative stress sustained by cells. All malignancies and corresponding tissues analyzed in this work were stained either by the anti-c-Cbl (left column) or by the anti-APE1 (right column). NT: Non Tumoral Tissue; T: Tumour Tissue; W: Weak Expression; H: High Expression; Nd: Not Done.