Authors & Year |
N cases |
Type of study |
Age
(yrs) |
Good PS (%) |
Debulk surg (%) |
Alkyl (%) |
MGMT assayed (%) |
MGMT meth (%) |
Deaths (%) |
3 mos |
6 mos |
MGMT methylation prognostic/predictive |
Balañà et al.[21] |
70 |
reta,b |
64 |
88.6 |
85.7 |
98.6 |
100 |
38.6 |
5.7 |
17.1 |
Brandes et al.[22] |
103 |
triala,b |
53 |
92 |
99 |
100 |
100 |
35 |
0 |
1.9 |
Cao et al.[23] |
73 |
reta |
55 |
54.2 |
91.6 |
100 |
100 |
60.3 |
1.4 |
8.2 |
Crinière et al.[24] |
77 |
reta |
58 |
63 |
NA |
100 |
100 |
58.4 |
1.3 |
6.5 |
Dunn et al.[20] |
109 |
reta,b |
55 |
84 |
76 |
100 |
100 |
53.2 |
3.7 |
15.6 |
Ellingson et al.[25] |
358 |
reta |
56.4 |
NAc |
NA |
NA |
100 |
36 |
1.1 |
5 |
Etcheverry et al.[26] |
50 |
prosa |
57.5 |
NAd |
NA |
100 |
100 |
60 |
8 |
18 |
Felsberg et al.[27] |
66 |
prosa,b |
56 |
82 |
100 |
100 |
100 |
39.4 |
0 |
1.5 |
Gilbert et al.[5] |
760 |
triala,b |
NAe |
100 |
97 |
100 |
100 |
32.1 |
0.8 |
6.7 |
Hegi et al.[3] |
106 |
triala,b |
56 |
87.3 |
83.8 |
100 |
100 |
43.4 |
1.9 |
10.4 |
Karayan-Tapon et al.[28] |
81 |
reta |
61 |
64.2 |
NA |
100 |
100 |
67.9 |
0 |
2.5 |
Lai et al.[29] |
141 |
trial+ reta,b |
58 |
96.1 |
86.2 |
100 |
100 |
40.4 |
0.7 |
7.1 |
Lakomy et al.[30] |
38 |
reta,b |
53 |
95 |
100 |
100 |
100 |
31.6 |
2.6 |
7.9 |
Metellus et al.[31] |
61 |
prosa,b |
59 |
34.4 |
100 |
100 |
100 |
37.7 |
0 |
1.6 |
Morandi et al.[32] |
159 |
reta |
57 |
100 |
NA |
100 |
100 |
44 |
1.9 |
6.3 |
Motomura et al.[33] |
68 |
reta |
55 |
66.2 |
NA |
100 |
100 |
33.8 |
1.5 |
2.9 |
Stupp et al.[34] |
45 |
triala,b |
57 |
92 |
83 |
100 |
100 |
51.1 |
2.2 |
8.9 |
Weiler et al.[35] |
41 |
trialb |
56 |
100 |
90 |
100 |
95.1 |
41 |
0 |
2.4 |
Weller et al.[36] |
185 |
prosa,b |
61.5 |
84 |
90 |
100 |
100 |
43.8 |
2.7 |
7 |
MGMT methylation no prognostic/predictive |
Clarke et al.[10] |
85 |
trial |
56.3 |
73 |
78 |
100 |
56.5 |
18.8 |
0 |
4.7 |
Costa et al.[11] |
80 |
ret |
56 |
53.3 |
90 |
100 |
100 |
47.5 |
6.3 |
23.8 |
El Hindyet al.[12] |
160 |
ret |
58 |
NA |
59.4 |
37.5 |
66.3 |
18.9 |
13.8 |
31.9 |
Iliadiset al.[13] |
65 |
pros |
59 |
90 |
90.8 |
100 |
35.4 |
43.5 |
1.5 |
7.7 |
Lam&Chambers et al.[14] |
101 |
ret |
56.5 |
47 |
68 |
100 |
100 |
49.5 |
3 |
15.8 |
Martinez et al.[15] |
46 |
ret |
60.6 |
NA |
NA |
100 |
100 |
32.6 |
2.2 |
8.7 |
Mellai et al.[9] |
67 |
ret |
60.3 |
NA |
100 |
35 |
100 |
29.9 |
13.4 |
31.3 |
Schaich et al.[16] |
63 |
ret |
63 |
84 |
NA |
100 |
100 |
34.9 |
0 |
4.8 |
Tang et al.[17] |
79 |
ret |
NA |
57 |
100 |
100 |
100 |
32.9 |
5.1 |
15.2 |
a, MGMT prognostic for longer overall survival; b, MGMT predictive for longer progression-free survival when treated with alkylating drugs; c, mean KPS 72.4; d, median
KPS 78.6. Alkyl, treated with alkylating drugs; e, 26.8 of patients with age < 50 yrs. Debulk surg: debulking surgery; Meth: Methylated; MGMT: O6-Methylguanine DNAMethyltransferase;
NA: Not Available; Pros: Prospective; PS: Performance Status; Ret: Retrospective |