| Parameter |
MGMT promoter methylation |
P |
OR (95 CI) |
| Predictive/
prognostic |
No predictive/
prognostic |
| N cases |
2591 |
746 |
NA |
NA |
| Retrospective studies (%) |
45.3 |
79.9 |
<0.0001a |
4.7958 (3.946-5.8285) |
| Age (yrs) |
57.3 |
58.3 |
0.1894b |
NA |
| Good PS (%) |
88.4 |
65.3 |
<0.0001a |
0.2481 (0.1971-0.3123) |
| Debulking surgery (%) |
92.6 |
79.6 |
<0.0001a |
0.3115 (0.2399-0.4046) |
| Treated with alkylating drugs (%) |
100 |
80.7 |
<0.0001a |
0.0019 (0.0003-0.0134) |
| MGMT methylated |
40.4 |
34.3 |
0.00617a |
0.7699 (0.6403-0.9258) |
| Deaths at 3 months (%) |
1.5 |
6 |
<0.0001a |
4.3128 (2.7781-6.6954) |
| Deaths at 6 months (%) |
6.9 |
18.1 |
<0.0001a |
2.9952 (2.3546-3.8102) |
A: Chi-Square Test; B: Student’s t Test; CI: Confidence Interval; MGMT: O6-Methylguanine DNA-Methyltransferase; NA:Not Applicable; OR: Odds Ratio; PS: Performance
Status |
