Parameter MGMT promoter methylation P OR (95 CI)
Predictive/ prognostic No predictive/ prognostic
N cases 2591 746 NA NA
Retrospective studies (%) 45.3 79.9 <0.0001a 4.7958 (3.946-5.8285)
Age (yrs) 57.3 58.3 0.1894b NA
Good PS (%) 88.4 65.3 <0.0001a 0.2481 (0.1971-0.3123)
Debulking surgery (%) 92.6 79.6 <0.0001a 0.3115 (0.2399-0.4046)
Treated with alkylating drugs (%) 100 80.7 <0.0001a 0.0019 (0.0003-0.0134)
MGMT methylated 40.4 34.3 0.00617a 0.7699 (0.6403-0.9258)
Deaths at 3 months (%) 1.5 6 <0.0001a 4.3128 (2.7781-6.6954)
Deaths at 6 months (%) 6.9 18.1 <0.0001a 2.9952 (2.3546-3.8102)
A: Chi-Square Test; B: Student’s t Test; CI: Confidence Interval; MGMT: O6-Methylguanine DNA-Methyltransferase; NA:Not Applicable; OR: Odds Ratio; PS: Performance Status
Table 2: Univariate analysis of clinical data in studies assessing the relationship between MGMT methylation and prognosis.