Factor Coeff SE Coeff/ SE χ2 value P-value OR 95% CI constant -36.921 20.620 -1.791 3.206 0.0734 9.234 x10-17 2.582x10-34-33.018 N cases 0.006 0.018 0.351 0.123 0.7256 1.006 0.971-1.043 median age 0.520 0.331 1.572 2.473 0.1158 1.683 0.880-3.220 MGMT methylated cases 4.418 2.390 1.848 3.416 0.0646 82.894 0.765-8979.118 Retrospective study 0.113 1.515 0.075 0.006 0.9406 1.120 0.057-21.835 Treated with alkylating drugs -9.991 5.176 -1.930 3.726 0.0536 4.583 x10-5 1.799x10-9-1.167 Deaths at 6 mos 0.417 0.172 2.429 5.902 0.0151 1.517 1.084-2.124 CI: Confidence Interval; Coeff: Coefficient; Mgmt: O6-Methylguanine Dna-Methyltransferase; OR: Odds Ratio; SE: Standard Error

Table 4: Multivariate analysis of factors potentially affecting the predictive/prognostic role of MGMT methylation in a study cohort modeled with 6-month death rate.