MGMT promoter methylation status Deaths at 3 months (%) P OR (95% CI) Studies with MGMT methylation prognostic/predictive Studies with MGMT methylation no prognostic/predictive Methylated 0.8 4.4 0.0003 6.0291 (2.2331 – 16.2776) Unmethylated 1.9 4.6 0.001 2.4363 (1.2761 – 4.6516) CI: Confidence Interval; MGMT: O6-Methylguanine DNA-Methyltransferase; OR: Odds Ratio

Table 6: Mortality at 3 months according with MGMT status in reviewed studies.