CODE |
R |
X |
IC50 μg/mL1,2 |
MCF-7 |
ISHIKAWA |
MDA-MB-231 |
6a |
C6H5 |
CO |
0.63 |
0.23 |
0.74 |
6b |
4-CH3-C6H4 |
CO |
0.70 |
0.44 |
1.02 |
6c |
4-OCH3-C6H6 |
CO |
0.93 |
0.21 |
0.78 |
6d |
4-C2H5-C6H6 |
CO |
0.43 |
0.01 |
0.37 |
6e |
4-C3H7-C6H6 |
CO |
3.71 |
0.75 |
3.26 |
6f |
4-C4H9-C6H6 |
CO |
3.05 |
0.96 |
7.03 |
6g |
4-tert-C4H9-C6H6 |
CO |
21.34 |
7.12 |
>30.84 |
6h |
4-F-C6H6 |
CO |
>27.03 |
8.3 |
>27.03 |
6i |
4-Cl-C6H6 |
CO |
0.71 |
0.61 |
0.80 |
6j |
4-Br-C6H6 |
CO |
0.7 |
0.02 |
4.34 |
6k |
4-CF3-C6H6 |
CO |
3.15 |
0.5 |
4.85 |
6l |
3,4,5-tri-OCH3-C6H2 |
CO |
>34.24 |
>34.24 |
>34.24 |
6m |
4-NO2-C6H6 |
CO |
18.23 |
8.39 |
>29.73 |
6n |
C6H5 |
SO2 |
>28.84 |
>28.84 |
>28.84 |
6o |
4-CH3-C6H6 |
SO2 |
>30.24 |
>30.24 |
>30.24 |
6p |
4-OCH3-C6H6 |
SO2 |
1.27 |
0.45 |
0.76 |
6q |
4-C2H5-C6H6 |
SO2 |
>31.64 |
>31.64 |
>31.64 |
6r |
4-C4H9-C6H6 |
SO2 |
>34.45 |
>34.45 |
>34.45 |
6s |
2-C4H3O |
CO |
>24.23 |
>24.23 |
>24.23 |
6t |
6-Cl-C5H3N |
CO |
>28.77 |
5.62 |
>28.77 |
6u |
2-Cl-6-CH3-C5H2N |
CO |
>30.18 |
>30.18 |
>30.18 |
6v |
C7H5NS |
CO |
15.0 |
8.98 |
13.11 |
6w |
6-CF3-C5H3N |
CO |
22.51 |
8.57 |
>32.13 |
6x |
2,6-di-Cl-5-F-C5HN |
CO |
>34.02 |
9.95 |
>34.02 |
THIQ |
 |
- |
>13.32 |
>13.32 |
>13.32 |
|
TAMOXIFEN |
|
5.14 |
4.55 |
5.64 |
1The data represent the average of triplicate determinations at various concentrations
2The IC50 values were determined from the graphs (GraphPad Prism) using mean values of data points at various concentrations |