CODE R X IC50 μg/mL1,2
MCF-7 ISHIKAWA MDA-MB-231
6a C6H5 CO 0.63 0.23 0.74
6b 4-CH3-C6H4 CO 0.70 0.44 1.02
6c 4-OCH3-C6H6 CO 0.93 0.21 0.78
6d 4-C2H5-C6H6 CO 0.43 0.01 0.37
6e 4-C3H7-C6H6 CO 3.71 0.75 3.26
6f 4-C4H9-C6H6 CO 3.05 0.96 7.03
6g 4-tert-C4H9-C6H6 CO 21.34 7.12 >30.84
6h 4-F-C6H6 CO >27.03 8.3 >27.03
6i 4-Cl-C6H6 CO 0.71 0.61 0.80
6j 4-Br-C6H6 CO 0.7 0.02 4.34
6k 4-CF3-C6H6 CO 3.15 0.5 4.85
6l 3,4,5-tri-OCH3-C6H2 CO >34.24 >34.24 >34.24
6m 4-NO2-C6H6 CO 18.23 8.39 >29.73
6n C6H5 SO2 >28.84 >28.84 >28.84
6o 4-CH3-C6H6 SO2 >30.24 >30.24 >30.24
6p 4-OCH3-C6H6 SO2 1.27 0.45 0.76
6q 4-C2H5-C6H6 SO2 >31.64 >31.64 >31.64
6r 4-C4H9-C6H6 SO2 >34.45 >34.45 >34.45
6s 2-C4H3O CO >24.23 >24.23 >24.23
6t 6-Cl-C5H3N CO >28.77 5.62 >28.77
6u 2-Cl-6-CH3-C5H2N CO >30.18 >30.18 >30.18
6v C7H5NS CO 15.0 8.98 13.11
6w 6-CF3-C5H3N CO 22.51 8.57 >32.13
6x 2,6-di-Cl-5-F-C5HN CO >34.02 9.95 >34.02
THIQ - >13.32 >13.32 >13.32
  TAMOXIFEN   5.14 4.55 5.64
1The data represent the average of triplicate determinations at various concentrations 2The IC50 values were determined from the graphs (GraphPad Prism) using mean values of data points at various concentrations
Table 1: IC50 values (μg/mL) for compounds 6a-x tested against MCF-7, MDA-MB231 and Ishikawa Cancer Cells.