Group Days of treatment Dose of drug (mg/kg) # of mice per group 1 Untreated controls - - 5 2 Colchicine treated 9,12,15 2, 2, 4 5 3 PCL-Colchicine treated 9,12,15 2, 2, 4 5

Table 2: Experimental Design for therapeutic response studies; MCA-205 cells were injected on day 1.