Figure 1: Local infection by AdhVASH1 inhibited tumor angiogenesis in the peritoneum. A: AdhVASH1 or AdLacZ (1x109 pfu) viruses were injected in the peritoneal cavity, and 2×106 HM-1 cells were subsequently inoculated intraperitoneally. Eleven days after the inoculation of HM-1 cells, the peritoneum was inspected. The sagittal section of peritoneum was stained with hematoxylin and eosin. B: The thickness of peritoneal tumor was measured and compared between AdLacZ (N=6) and AdhVASH1 (N=6) groups. Scale bar=200 μm. Means and SDs are shown. C: Microvessels of the peritoneum were immunostained with antibody against CD31. Scale bar=200 μm. D: The vascular area positive for CD31 was quantified and compared between AdLacZ (N=4) and AdhVASH1 (N=4) groups. Means and SDs are shown.