| Marker |
Type of marker |
Source |
Stem-like characteristics |
Reference |
| Side Population |
Biochemical |
Mouse ovarian cancer cell lines
Primary ovarian xenografts cell lines
Human ovarian cancer cell line
Patients ascites |
Tumorigenicity, chemoresistance, asymmetric division
Tumorigenicity, high proliferation rate, low apoptotic events
Tumorigenicity, chemoresistance, low apoptotic events, clonogenicity, high expression of stemness genes
Tumorigenicity, chemoresistance, low apoptotic events |
[20]
[79]
[80], [81]
[81] |
| ALDH |
Biochemical |
Human ovarian cancer cell lines,
ovarian tumor xenografts |
Tumorigenicity, chemoresistance, self-renewal |
[68] |
| CD133 |
Surface marker |
Human ovarian cancer cell lines
Primary ovarian tumors
Primary ovarian xenografts |
Tumorigenicity, chemoresistance, asymmetric division, self-renewal
Clonogenicity, high proliferation rate
Tumorigenicity |
[18]
[72]
[73] |
| CD117 |
Surface marker |
Primary ovarian tumor xenografts |
Tumorigenicity, chemoresistance, self-renewal |
[78] |
| CD24 |
Surface marker |
Primary ovarian cell line |
Chemoresistance, high expression of stemness genes, self-renewal |
[26] |
| ALDH+/CD133+ |
Biochemical+
urface marker |
Human ovarian cancer cell lines, patient tumors
Primary ovarian tumors and ascites |
Tumorigenicity, chemoresistance, spheres formation, angiogenic capacity
Tumorigenicity, spheres formation |
[74]
[22] |
| ALDH+/CD44+ |
Biochemical+
surface marker |
Human ovarian cancer cell lines |
Chemoresistance |
[75] |
| CD44+/CD24- |
Surface marker |
Human ovarian cancer cell lines
Human ovarian cancer cell lines |
Tumorigenicity, chemoresistance, self-renewal, spheres formation
Chemoresistance, clonogenicity |
[76]
[77] |
| CD44+/Myd88+ |
Surface marker+ cytoplasmatic adaptor protein |
Primary ovarian tumors and ascites |
Tumorigenicity, chemoresistance, low apoptotic events, self-renewal, spheres formation |
[19] |
| CD44+/CD117+ |
Surface marker |
Primary ovarian tumor spheroids |
Tumorigenicity, chemoresistance, high expression of stemness markers, self-renewal, spheres formation |
[24] |
