| Marker |
Source |
Features |
Reference |
| E-cadherin |
Human ovarian tumor samples
Human ovarian tumor samples
Human ovarian tumor samples |
Reduced expression in primary tumors, but higher expressed in carcinoma effusions
Low E-cad. mRNA expression in carcinoma effusions correlates with poor survival
High levels correlates with a better survival |
[36]
[37]
[38] |
| Claudins |
Ovarian cell lines human tissues
Human ovarian tumor samples
Human ovarian tumor samples |
Higher expression in ovarian cancer than in normal tissue
Higher expression in ovarian cancer than in normal tissue
Higher expression in primary tumors, ascites fluid and metastasis than in normal tissue |
[40]
[41]
[42] |
| Alpha2beta1 integrin |
Ovarian cancer cell lines |
Higher expression in spheroid cultures respect to monolayer cultures |
[43] |
| N-cadherin
Vimentin |
Ovarian cancer stem-like spheres |
Higher expression in tumor-initiating sphere cultures than in more differentiated cell cultures |
[27] |
| N-cadherin, P-cadherin |
Human ovarian tumor samples |
Expression of mesenchymal markers defined a subtype of ovarian cancer
associated with poor OS |
[45] |
| Twist |
Ovarian cancer cell lines |
Upregulation associated with chemoresistance |
[58] |
| TLR, TGFβ, ECM, FN1, PDGFRB, COL3A1 |
Human ovarian tumor samples |
High protein levels associated with chemoresistance |
[59] |
| Snail, slug, Twist, MMP2 |
Human ovarian tumor samples, ovarian cancer cell lines |
Higher expression in chemoresistant than in sensitive samples, associated with stemness phenotype |
[57] |
| TGFβ |
Human ovarian tumor samples
Ovarian cancer cell lines |
Upregulation of this pathway correlatesd with chemoresistance |
[60]
[63] |
| E-cadherin, beta catenin, NF-kappaB, TGFβ, Wnt signaling |
Human ovarian tumor samples |
Overexpression associated with poor prognosis |
[61] |
| Snail, slug, Twist2, Zeb2 |
Human ovarian tumor samples, ovarian cancer cell lines |
Upregulation associated with chemoresistance |
[14] |
| EndothelinA |
Ovarian cancer cell lines |
Upregulation associated with chemoresistance |
[62] |
OS: Overall Survival
TLR: Toll-like receptor
TGFβ: Transforming Growth Factor β
ECM: Extra-Cellular Matrix
FN1: Fibronectin1
PDGFRB: platelet-derived growth factor receptor
COL3A1: collagen3α1