HGSC CCC EC MC LGSC
Precursor lesions Serous tubal intraepithelial carcinoma Endometriosis Endometriosis Unknown Serous borderline tumor
Molecular genetics P53, BRCA1, BRCA2. HRD with genomic instability PI3K, ARID1A, MSI PTEN, ╬▓catenin, ARID1A, MSI KRAS, HER2 BRAF, KRAS, NRAS
Potential targets PARPi, Angiogenesis Angiogenesis PI3K Hormone receptors, mTOR HER2/neu BRAF, MEK
HRD-homologous recombination deficiencies (NF1, RB1, CDK12)
Table 1: Sub classification of epithelial ovarian cancers [amended from 4].