HGSC CCC EC MC LGSC Precursor lesions Serous tubal intraepithelial carcinoma Endometriosis Endometriosis Unknown Serous borderline tumor Molecular genetics P53, BRCA1, BRCA2. HRD with genomic instability PI3K, ARID1A, MSI PTEN, βcatenin, ARID1A, MSI KRAS, HER2 BRAF, KRAS, NRAS Potential targets PARPi, Angiogenesis Angiogenesis PI3K Hormone receptors, mTOR HER2/neu BRAF, MEK HRD-homologous recombination deficiencies (NF1, RB1, CDK12)

Table 1: Sub classification of epithelial ovarian cancers [amended from 4].