Figure 3: Combination treatment with dUb and EDL-360 induce synergetic cell death in glioma cultures. Glioma and normal astrocytic cultures were plated into 96-well plates and treated with either EDL-360 (1, 5, 10 μM) or 40 μM dUb as a single treatment, or in combination. The cultures were incubated with the drug(s) for 5 days and cell viabilities were measured by MTT assay. (A), Chemical structure of dUb. Viable astrocytes (B), U87 (C) and LN18 (D) were calculated as a percentage of vehicle treated cells. Bars represent the means; whiskers represent the standard deviation (±SD); * p<0.05.