Figure 4: EDL-360 reduces tumor growth in human glioma xenograft mouse model. U87Luc cells were injected into the right flank of the mice. Once the tumor became palpable in the mice, treatment was initiated. A, Weight of the mice was obtained twice a week. There was no sign of toxicity or weight lose in EDL-360 treated group compared to the control mice. B, Tumor dimensions were obtained using digital caliper to determine tumor volume. C, Bioluminescence signal from control and treated mice showed an obvious decrease in tumor viable cells after 17 days of treatment. D, Quantification of bioluminescence signal showed a continuous tumor growth in the control mice. Bars represent the means; whiskers represent the standard deviation (±); * p<0.05.