Figure 2: Modulation of pro-inflammatory genes under hypoxic stimulation. The expression levels of VEGF, CXCR4, RAGE, HMOX, PTX3, P2X7R and COX2 were evaluated by RT PCR at different times of hypoxia in MSTO and MPP cells. Values are expressed as the ratio between hypoxic and normoxic (t=0, value=1) conditions and represent the mean ± SE of three different experiments. 18S rRNA was used as housekeeping gene. Horizontal bars at the top of each graphic indicate significant values (P≤0.05).