Parameters Univariate analysis Multivariate analysis
HR 95% CI p-value HR 95% CI p-value
Age, years ≤ 60 vs >60 2.60 1.3-12.82 0.01 0.26 0.03-2.24 0.22
Type of first line-chemotherapy Single agent vs combination Antracyclines vs Taxanes vs other 0.87 0.68 0.32-2.34 0.76-3.63 0.7 0.08 - -    
Ki-67 ≤ 20% vs >20% 2.33 1.08-4.65 0.005 2.38 1.11-5.62 0.04
Necrosis negative vs positive 0.39 0.04-1.13 0.07 -    
Lympho-vascular invasion negative vs positive 0.40 0.08-0.85 0.02 0.24 0.02-2.58 0.24
Visceral disease yes vs not 0.48 0.16-1.19 0.10 -    
e-cadherin negative vs positive 0.38 0.13-1.37 0.15 -    
Aldh1 negative vs positive 0.73 0.25-1.98 0.5 -    
CK5/6 negative vs positive 0.54 0.15-1.45 0.19 -    
AR negative vs positive 2.57 1.15-10.53 0.02 2.19 1.52-5.91 0.04
Table 2: Univariate and multivariate Cox regression analysis of factors associated with progression-free survival in advanced triple negative breast cancer.