| Protein family/type |
Targeting molecules |
Function |
Study samples |
References |
| High mobility group (HMG) box protein |
TFAM |
mtDNA transcription, maintenance, coating and packaging |
Human Cell lines and tissue samples |
[59,69,70] |
| Stomatin/prohibitin/flotillin/HflK/C (SPFH) domain containing protein |
PHB-1 |
Express in mitochondria, nucleus, cytosol and maintain communication among them |
Human Cell lines and tissue samples |
[28,78-80,95] |
| Anti-apoptotic B-cell lymphoma 2 (BCL-2) family protein |
MCL-1 |
Optic atrophy 1 (OPA-1) mediated mitochondrial fusion |
Human Cell lines |
[81-84,86] |
| A member of the Bcl-2 family |
BNIP3 |
Induction of cell death through mitochondrial dysfunction in response to hypoxia inducible factor-1 (HIF-1) |
Human Cell lines |
[89-91] |
| Mitochondrial methylation-controlled protein |
MCJ |
Involved in mitochondrial import and regulation of mitochondrial permeability transition pore (MPTP) complex |
Human Cell lines |
[25,27,87,88] |
| Dynamin-related protein |
DRP-1 |
Important key fission protein involved in mitochondrial dynamics |
Human Cell lines and in vivo in mice |
[26] |
| Nuclear respiratory factor |
NRF-1 |
Transcription of TFAM |
Multicenter case-control study with Caucasian EOC patients |
[57] |
| Peroxisome proliferator-activated receptor gamma coactivator |
PGC-1α |
Transcription of essential factors for mitochondrial biogenesis including NRF1 and NRF2 |
Multicenter case-control study with Caucasian EOC patients |
[57] |
