Protein family/type Targeting molecules Function Study samples References
High mobility group (HMG) box protein TFAM mtDNA transcription, maintenance, coating and packaging Human Cell lines and tissue samples [59,69,70]
Stomatin/prohibitin/flotillin/HflK/C (SPFH) domain containing protein PHB-1 Express in mitochondria, nucleus, cytosol and maintain communication  among them Human Cell lines and tissue samples [28,78-80,95]
Anti-apoptotic B-cell lymphoma 2 (BCL-2) family protein MCL-1 Optic atrophy 1 (OPA-1) mediated mitochondrial fusion Human Cell lines [81-84,86]
A member of the Bcl-2 family BNIP3 Induction of cell death through mitochondrial dysfunction in response to hypoxia inducible factor-1 (HIF-1) Human Cell lines [89-91]
Mitochondrial methylation-controlled protein MCJ Involved in mitochondrial import and regulation of mitochondrial permeability transition pore (MPTP) complex Human Cell lines [25,27,87,88]
Dynamin-related protein DRP-1 Important key fission protein involved in mitochondrial dynamics Human Cell lines and in vivo in mice [26]
Nuclear respiratory factor NRF-1 Transcription of TFAM Multicenter case-control study with Caucasian EOC patients [57]
Peroxisome proliferator-activated receptor gamma coactivator PGC-1α Transcription of essential factors for mitochondrial biogenesis including¬† NRF1 and NRF2 Multicenter case-control study with Caucasian EOC patients [57]
Table 1: Possible anticancer targets involved in MtBIO in ovarian cancer.