Figure 1: The level of BRUCE protein is upregulated in breast tumor tissues. IHC of BRUCE on normal breast tissue (A) and primary breast tumors (B-D) on paraffin array slides with tumor tissue outlined in red circles and adjacent normal tissues in blue circles; scale bar: 20 mircometer. Statistical analysis of BRUCE IHC staining (E) was based on clinic scoring criteria described in the Methods. The values represent average scores of normal vs tumor tissues. Variation represents standard error of the mean (SEM). Student’s t-test, P=0.013; (p<0.05 was regarded significant; one-tailed test).