Study Year Number of patients with known cause of death Deaths caused by BSM progression (%) Deaths caused by systemic disease (%) Deaths caused by non-BSM intracranial disease (%) Other cause of death Kilburn 2014 NR         Peterson 2014 NR         Jung 2013 NR         Sengoz 2013 NR         Kawabe 2012 175 2% 89% 9%   Leeman 2012 20   60%     LI 2012 28 4% 68% 29%   Lin 2012 NR         Yoo 2011 15 7% 60% 33%   Valery 2011 19   58%   42% neurological relapse Hatiboglu 2011   2% 71% 7%   Kelly 2011 18 0% 83% 17%   Koyfman 2010 NR         Samblas 2009 24 4% 42% 43% 4% MI, 4% chemotherapy toxicity Lorenzoni 2009 NR         Kased 2008 19 5% 63% 32%   Hussain 2007     55% 23% 22% unknown Fuentes 2006 16 13% 50% 38%   Yen 2006 43 7% 79% 14%   Shuto 2003     NR   28% metastatic brain tumors Huang 1999     NR   3 from new tumor growth, 1 new tumor + sys dz

Abbreviations: COD – cause of death

Table 3: Reported cause of death in study participants [1,2,4-22].