Groups Group I Group II Group III Group IV Group V
SOD (U/min/mg protein) 4.87 ± 0.09 4.34 ± 0.078 a, ns 2.09 ± 0.068 a,*** 3.27 ± 0.043b,** 4.03 ± 0.062 b,***
CAT (U/min/mg protein) 30.54 ± 0.53 28.61 ± 0.34 a, ns 18.37 ± 0.29 a,*** 23.42 ± 0.54 b,* 27.51 ± 0.58b,**
GPx(nmol NADPH oxidized/min/mg protein) 91.2 ± 0.31 85.7 ± 0.31 a, ns 58.7 ± 0.46 a,*** 64.9 ± 1.47b,ns 82.4 ± 0.52 b,***
GST(nmol CDNB conjugate/min/mg protein) 387.60 ± 13.64 376.50 ± 11.3 a, ns 174.20 ± 11.7 a,*** 239.5 ± 4.8 b,** 368.3 ± 12.7 b,***
GSH (nmol GSH/mg tissue) 2.85 ± 0.18 2.23 ± 0.18 a, ns 1.21 ± 0.22 a,*** 1.68 ± 0.46b,ns 2.35 ± 0.21 b,***
GR (nmol GR/mg tissue) 3.20 ± 0.44 2.98 ± 0.31 a, ns 1.97 ± 0.27 a,*** 2.61 ± 0.40 b, ** 3.07 ± 0.53 b,***
Values are expressed as mean ± SEM for Six animals. Group I: Normal control; Group II: PH-control; Group III: NDEA; Group IV: NDEA+SIB (25 mg/kg/day); Group V: NDEA+SIB (50 mg/kg/day). Comparisons: a = groups II and III with group I; b = group IV and V with group III. Significant: nsp>0.05; *p<0.05; **p<0.01; ***p<0.001.
Table 3: Effect of Silibinin (SIB) on serum antioxidant status of NDEA-induced liver cancer rats.