Effect of SIB

Groups		Group I	Group II	Group III	Group IV	Group V
SOD (U/min/mg protein)		4.87 ± 0.09	4.34 ± 0.078 ^{a, ns}	2.09 ± 0.068 ^a,***	3.27 ± 0.043^b,**	4.03 ± 0.062 ^b,***
CAT (U/min/mg protein)		30.54 ± 0.53	28.61 ± 0.34 ^{a, ns}	18.37 ± 0.29 ^a,***	23.42 ± 0.54 ^b,*	27.51 ± 0.58^b,**
GPx(nmol NADPH oxidized/min/mg protein)		91.2 ± 0.31	85.7 ± 0.31 ^{a, ns}	58.7 ± 0.46 ^a,***	64.9 ± 1.47^{^b,ns}	82.4 ± 0.52 ^b,***
GST(nmol CDNB conjugate/min/mg protein)	387.60 ± 13.64		376.50 ± 11.3 ^{a, ns}	174.20 ± 11.7 ^a,***	239.5 ± 4.8 ^b,**	368.3 ± 12.7 ^b,***
GSH (nmol GSH/mg tissue)	2.85 ± 0.18		2.23 ± 0.18 ^{a, ns}	1.21 ± 0.22 ^a,***	1.68 ± 0.46^b,ns	2.35 ± 0.21 ^b,***
GR (nmol GR/mg tissue)	3.20 ± 0.44		2.98 ± 0.31 ^{a, ns}	1.97 ± 0.27 ^a,***	2.61 ± 0.40 ^{b, **}	3.07 ± 0.53 ^b,***

Values are expressed as mean ± SEM for Six animals. Group I: Normal control; Group II: PH-control; Group III: NDEA; Group IV: NDEA+SIB (25 mg/kg/day); Group V: NDEA+SIB (50 mg/kg/day). Comparisons: a = groups II and III with group I; b = group IV and V with group III. Significant: ^nsp>0.05; *p<0.05; **p<0.01; ***p<0.001.

Table 3: Effect of Silibinin (SIB) on serum antioxidant status of NDEA-induced liver cancer rats.