Groups Group I Group II Group III Group IV Group V SOD(U/mg protein) 8.62 ± 0.32 8.04 ± 0.64 a, ns 4.45 ± 0.72 a,*** 6.36 ± 0.87 b, ** 8.10 ± 0.49b,*** CAT (U/mg protein) 60.53 ± 1.23 58.23 ± 1.40 a, ns 39.26 ± 1.67 a,*** 47.66 ± 1.5 b, * 56.16 ± 1.62b,*** GPx(nmol NADPH oxidized/min/mg protein) 92.45 ± 2.32 89.34 ± 1.24 a, ns 43.05 ± 2.21 a,*** 58.15 ± 1.13 b, * 72.34 ± 1.15b,*** GST(nmol CDNB conjugate/min/mg protein) 179.43 ± 2.69 181.45 ± 5.12 a, ns 92.82 ± 1.85 a,*** 129.11 ± 2.32 b, * 162.18 ± 3.15b,*** GSH (nmol GSH/mg tissue) 1.52 ± 0.12 1.48 ± 0.14 a, ns 0.49 ± 0.09 a,*** 0.85 ± 0.06 b, ** 1.43 ± 0.12b,*** Ascorbic acid 8.82 ± 0.13 8.12 ± 0.15 a, * 5.23 ± 0.19 a,*** 6.69 ± 0.13 b, ** 7.79 ± 0.08b,*** α-Tocopherol 6.14 ± 0.19 5.95 ± 0.25 a, ns 3.09 ± 0.12 a,*** 4.12 ± 0.23 b, * 5.85 ± 0.15b,***

Values are expressed as mean ± SEM for Six animals. Group I: Normal control; Group II: PH-control; Group III: NDEA; Group IV: NDEA+SIB (25 mg/kg/day); Group V: NDEA+SIB (50 mg/kg/day). Comparisons: a = groups II and III with group I; b = group IV and V with group III. Significant: nsp>0.05; *p<0.05; **p<0.01; ***p<0.001.

Table 4:Effect of Silibinin (SIB) on serum antioxidant status of NDEA-induced liver cancer rats.