Figure 4: Assessment of apoptosis induction in colorectal cancer cells by L. fermentum NCIMB 5221. Both the probiotic supernatant (PS) and the conditioned cell culture medium (CM) of L. fermentum NCIMB 5221 had induced apoptosis in SW-480 cells, when treated for (a, c) 12 h and (b, d) 24 h. The data values represent the mean ± SEM (n=4). *p < 0.05 compared with L. acidophilus ATCC 314 and L. rhamnosus ATCC 53103. L. a 314: L. acidophilus ATCC 314; L. rh 53103: L. rhamnosus ATCC 53103; L. f 5221: L. fermentum NCIMB 5221.