Grade Description Number of patients
1 Mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated 15/16 (94%)
2 Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental activities of daily living 8/16 (50%)
3 Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care activities of daily living 1/16 (6%)
4 Life-threatening consequences; urgent intervention indicated 0
5 Death related to AE 0
Table 3: Treatment-related toxicity according to CTCAEv4.0.