Function
Type I
Type II
Modulation of CD20 antigen Redistribute CD20 to lipid rafts
Yes
No
CDC
High
Minimal
ADCC
High
High
Homotypic adhesion
Weak
Strong
Apoptosis induction
Caspase dependent
Caspase independent Lysosome mediated
Table 2:
Following are general differences between type I and type II anti-CD20 mAbs.