Gene Official Full Name Function Log2 (Sutent/Control)
SCNN1G sodium channel, voltage-gated, type IX, alpha subunit   nociception signaling -1.276
SOD2 superoxide dismutase 2, mitochondrial  member of the iron/manganese superoxide dismutase family. -0.611
CCL20 chemokine (C-C motif) ligand 20  chemotactic activity for lymphocytes  -0.611
CP ceruloplasmin (ferroxidase) metalloprotein involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin -0.646
SSTR1 somatostatin receptor 1 Peptide hormones that regulate diverse cellular functions: neurotransmission, cell proliferation, and endocrine signaling 0,645
CRP C-reactive protein, pentraxin-related Host defense. recognize foreign pathogens and damaged cells of the host to initiate their elimination -0.654
FGB fibrinogen beta chain regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types -1.192
TFPI tissue factor pathway inhibitor  inhibits the activated factor X and VIIa-TF proteases -0.721
NEFL neurofilament, light polypeptide Neurofilaments comprise the axoskeleton that maintain the neuronal caliber -0.798
SCN9A sodium channel, voltage-gated, type IX, alpha subunit nociception signaling -0.577
C2 complement component 2 part of the classical pathway of the complement system -0.577
C4BPA complement component 4 binding protein, alpha controls activation of the complement cascade through the classical pathway -0.591
FABP7 fatty acid binding protein 7 play roles in fatty acid uptake, transport, and metabolism -0.150
LBP lipopolysaccharide binding protein involved in the acute-phase immunologic response to gram-negative bacterial infections -0.819
CXCL6 chemokine (C-X-C motif) ligand 6  chemokine involved in the innate immune response -1.038
MSTN myostatin regulators of cell growth and differentiation in both embryonic and adult tissues -0.468
IGFBP1 insulin-like growth factor binding protein 1 Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors -0.425
MMP9 matrix metallopeptidase 9 role in tumor-associated tissue remodeling 0.041
Table 3: Genes differentially expressed by patients treated with Sutent compared to controls. In bold are the genes that were validated by qRT-PCR.