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Figure 3: Quantitative Analysis of the expression S-ncmtRNA and AS-ncmtRNAs in samples representing cervical cancer progression. Non-tumoral samples showed a lower expression of AS-ncmtRNA with a significant difference (p-value = 0.0153), whereas normal raft organotypic culture showed high expression of both transcripts with no significant difference (p-value = 0.3367). A significant lower expression of AS-ncmtRNA was observed in CIN 1 and CIN 2 (p-value = 0.001), CIN3 (p-value = 0.0013) and invasive squamous cancer samples (p-value = 0.007). Down-regulation of AS-ncmtRNA was observed in all samples from the three later stages. |