Symbol Accession no. Gene category and name Classifier#
    Cyto skeleton-associated        
TGM3 NM_003245 Transglutaminase 3 A   C D
CLSP NM_017422 Calmodulin-like skin protein. Associated with TGM3.     C  
KRT17 NM_000422 Keratin 17.        
LOC144501 XM_096612 Similar to cytokeratin (AA 1-513)   B   D
SPRR1B NM_003125 Small proline-rich protein 1B (cornifin).        
ZNF185 NM_007150 Zinc finger protein 185 (LIM domain).   B    
KRT1 NM_006121 Homo sapiens keratin 1 (epidermolytic hyperkeratosis).        
TM7SF2 NM_003273 Transmembrane 7 superfamily member 2.   B    
AQP3 NM_004925 Aquaporin 3, Channering, water transport.     C  
C4.4A NM_014400 GPI-anchored metastasis-associated protein homolog. A      
FLJ11036 NM_018306 Hypothetical protein FLJ11036, transmembrane protein 40 (TMEM40),   B C D
    Cell adhesion        
CEACAM5 NM_004363 Carcinoembryonic antigen-related cell adhesion molecule 5.        
HSPC159 NM_014181 Homo sapiens galectin-related protein, HSPC159 protein.   B    
    Protease modification        
CSTB NM_000100 Cystatin B (stefin B) (CSTB), cysteine protease inhibitors     C  
KLK7 NM_005046 Kallikrein 7 (chymotryptic, stratum corneum) (KLK7), transcript variant 1 A   C  
MPN NM_031948 Pancreasin (MPN), novel tryptic serine peptidase expressed primarily by the pancreas     C D
WFDC12 NM_080869 WAP four-disulfide core domain 12 (WFDC12), functions as a protease inhibitor     C D
SLPI NM_003064 Secretory leukocyte protease inhibitor (antileukoproteinase), secreted inhibitor of serine proteases.   B C  
    Signal transduction        
RAB25 NM_020387 RAB25, member RAS oncogene family.        
S100A12 NM_005621 S100 calcium binding protein A12 (calgranulin C),involved in specific calcium-dependent signal transduction A      
    Cell growth/differentiation        
HOP NM_032495 Homeodomain-only protein, transcript variant 1 A      
CSRP2 NM_001321 Cysteine and glycine-rich protein 2, development and cellular differentiation. A   C  
CRABP2 NM_001878 Cellular retinoic acid binding protein 2.        
    Proliferation differentiation transformation        
CDA NM_001785 Cytidine deaminase. A B    
CBR3 NM_001236 Carbonyl reductase 3.   B   D
FOSB NM_006732 Homo sapiens FBJ murine osteosarcoma viral oncogene homolog B.        
ODC1 NM_002539 Ornithine decarboxylase 1. A   C  
SULT2B1 NM_004605 Sulfotransferase family, cytosolic, 2B, member 1. A   C D
RNASE7 NM_032572 Ribonuclease, RNase A family, 7.   B    
D4S234E NM_014392 DNA segment on chromosome 4 (unique) 234 expressed sequence.   B C D
UBD NM_006398 Homo sapiens ubiquitin D (UBD),        
APOBEC3A NM_145699 Homo sapiens apolipoprotein B mRNA editing enzyme, catalyticpolypeptide-like 3A.        
APM2 NM_006829 Adipose specific 2.     C  
# A, classifyer for LDA-1; B, for LDA-2; C, for LDA-3; D, for LDA-4, respectively.
Table 2: Marker genes down-regulated in advanced OSCCs.